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Article

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

6 Jan 2012

Abstract excerpt

SIRT1 is an NAD(+)-dependent histone deacetylase implicated in the establishment of the primitive hematopoietic system during mouse embryonic development. However, investigation of the role of SIRT1 in adult hematopoiesis has been complicated by the high perinatal mortality of SIRT1-deficient mice (SIRT1(-/-)). We performed a comprehensive in vivo study of the hematopoietic stem cell (HSC) compartment in adult...

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PMID: 22219225
DOI: 10.1182/blood-2011-09-377077

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