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Article

SIRT7: an influence factor in healthy aging and the development of age-dependent myeloid stem-cell disorders.

Leukemia - 1 Aug 2020

Kaiser Alexander, Schmidt Martin, Huber Otmar, Frietsch Jochen J, Scholl Sebastian, Heidel Florian H, Hochhaus Andreas, Müller Jörg P, Ernst Thomas

Abstract excerpt

Molecular alterations within the hematopoietic system influence cellular longevity and development of age-related myeloid stem-cell disorders like acute myeloid leukemia (AML) and chronic myeloid leukemia (CML). A reduced SIRT7-expression in aged murine hematopoietic stem cells (HSC) resulted in reduced longevity and increased proliferation. In this study we investigated age-related changes of SIRT7-expression in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32214204
DOI: 10.1038/s41375-020-0803-3
PMCID: PMC8318878

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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