Article

Prostaglandin E <sub>1</sub> as therapeutic molecule for Nephronophthisis and related ciliopathies

2022-01-23

Abstract excerpt

<h4>Summary</h4> Nephronophthisis (NPH) is an autosomal recessive tubulointerstitial nephropathy belonging to the ciliopathy disorders and known as the most common cause of hereditary end-stage renal disease in children. Yet, no curative treatment is available. The major gene, NPHP1 , encodes a protein playing key functions at the primary cilium and cellular junctions. Using an in cellulo medium-throughput drug...

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Literature Corpus work: c6c45820-3d53-5a31-9080-5c9fb2550d2e
DOI: 10.1101/2022.01.21.477191

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