Article

A Mutation-Agnostic EP2–cAMP–Driven Strategy Restores Ciliogenesis and Retinal Function in Ciliopathies

2025-12-05

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Defects in photoreceptor ciliary function cause retinal ciliopathies, a major group of inherited blinding disorders. Current therapies are limited by extensive genetic heterogeneity, small patient populations, and high development costs, underscoring the need for mutation-agnostic strategies. This study investigates cAMP signaling modulation as a means to enh...

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Literature Corpus work: 5edb2e65-e701-5796-ad6e-430eee2c19cb
DOI: 10.21203/rs.3.rs-8000675/v1

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