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Article

Genetic compensation prevents myopathy and heart failure in an in vivo model of Bag3 deficiency.

PLoS genetics - 1 Nov 2020

Diofano Federica, Weinmann Karolina, Schneider Isabelle, Thiessen Kevin D, Rottbauer Wolfgang, Just Steffen

Abstract excerpt

Mutations in the molecular co-chaperone Bcl2-associated athanogene 3 (BAG3) are found to cause dilated cardiomyopathy (DCM), resulting in systolic dysfunction and heart failure, as well as myofibrillar myopathy (MFM), which is characterized by protein aggregation and myofibrillar disintegration in skeletal muscle cells. Here, we generated a CRISPR/Cas9-induced Bag3 knockout zebrafish line and found the complete...

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Source

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Identifiers

PMID: 33137814
DOI: 10.1371/journal.pgen.1009088
PMCID: PMC7605898

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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