Article
[Establishment and preliminary mechanism study of the zebrafish strain of KIAA0196: A candidate pathogenic gene for heart development].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 28 Sept 2019
Bu Haisong, Yang Yifeng, Luo Xiaoyu, Hu Shijun, Gong Xueyang, Zhao Tianli
Abstract excerpt
OBJECTIVE: To explore the effects of KIAA0196 gene on cardiac development and the establishment of zebrafish strain. Methods: Peripheral blood and gDNA from patients were extracted. Copy number variation analysis and target sequencing were conducted to screen candidate genes. The KIAA0196 knockout zebrafish was generated by CRISPR/Cas9 to detect whether KIAA0196 deficiency could affect cardiac development....
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