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Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafish

21 Dec 2021

Abstract excerpt

Myosin heavy chain 7 (MYH7) is a major causative gene for hypertrophic cardiomyopathy, but the affected signaling pathways and therapeutics remain elusive. In this research, we identified ventricle myosin heavy chain like (vmhcl) as a zebrafish homolog of human MYH7, and we generated vmhcl frameshift mutants. We noted vmhcl-based embryonic cardiac dysfunction (VEC) in the vmhcl homozygous mutants and vmhcl-based...

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PMID: 34935644
DOI: 10.1172/jci.insight.154215

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Inhibition of mTOR or MAPK ameliorates vmhcl/myh7 cardiomyopathy in zebrafishPMID 34935644Read ↗

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