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Article

CYP3A422 and CYP3A53 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.

Nordic journal of psychiatry - 1 Jan 2023

Skryabin Valentin Yurievich, Franck Johan, Lauschke Volker Martin, Zastrozhin Mikhail Sergeevich, Shipitsyn Valery Valerievich, Bryun Evgeny Alekseevich, Sychev Dmitry Alekseevich

Abstract excerpt

BACKGROUND: Diazepam is one of the most commonly prescribed pharmaceuticals for the treatment of alcohol withdrawal syndrome (AWS). However, diazepam sometimes is ineffective, and some patients experience dose-dependent adverse drug reactions (ADR). Previous studies have shown that diazepam metabolism involves the CYP3A4 and CYP3A5 isoenzymes, whose activity is highly variable between individuals, which may...

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Share to Alcoholism
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 35471917
DOI: 10.1080/08039488.2022.2065531

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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