Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients.

Pharmacogenomics - 1 Oct 2011

Chen Chia-Hui, Wang Sheng-Chang, Tsou Hsiao-Hui, Ho Ing-Kang, Tian Jia-Ni, Yu Cheng-Jou, Hsiao Chin-Fu, Chou Sun-Yuan, Lin Yen-Feng, Fang Kai-Chi, Huang Chieh-Liang, Su Lien-Wen, Fang Yong-Chun, Liu Ming-Lun, Lin Keh-Ming, Hsu Ya-Ting, Liu Shu Chih, Chen Andrew Ch, Liu Yu-Li

Abstract excerpt

AIM: Methadone maintenance therapy is one of the standard treatments for heroin addiction. The isozyme CYP3A4 of the CYP system is one of the metabolic enzymes, as well as CYP2B6, responsible for the metabolism of methadone. The aim of the present study is to evaluate the potential use of genetic polymorphisms in CYP3A4 as biomarkers for the prediction of methadone treatment responses. MATERIALS & METHODS: A...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Areca
Share to Biomarkers, Pharmacological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Genetic Association Studies

Share to Heart Rate

Share to Heroin Dependence

Share to Methadone

Share to Substance Withdrawal Syndrome

Source

Identifiers

PMID: 21902501
DOI: 10.2217/pgs.11.103

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic polymorphisms in CYP3A4 are associated with withdrawal symptoms and adverse reactions in methadone maintenance patients.PMID 21902501Read ↗

UGT2B7 genetic polymorphisms are associated with the withdrawal symptoms in methadone maintenance patients.Semantic proximity Read ↗

Genetic polymorphisms in the opioid receptor mu1 gene are associated with changes in libido and insomnia in methadone maintenance patients.Semantic proximity Read ↗

Pharmacogenetic study of methadone treatment for heroin addiction: associations between drug-metabolizing gene polymorphisms and treatment efficacy.Semantic proximity Read ↗

Functional genetic polymorphisms in CYP2C19 gene in relation to cardiac side effects and treatment dose in a methadone maintenance cohort.Semantic proximity Read ↗

Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients.Semantic proximity Read ↗

CYP3A4*22 and CYP3A5*3 impact efficacy and safety of diazepam in patients with alcohol withdrawal syndrome.Semantic proximity Read ↗

The association of genetic polymorphisms in the κ-opioid receptor 1 gene with body weight, alcohol use, and withdrawal symptoms in patients with methadone maintenance.Semantic proximity Read ↗

FAAH rs324420 Polymorphism in People With Opioid and Methamphetamine Use Disorders: Psychological Associations.Semantic proximity Read ↗

Pharmacogenomics and Opioid Use Disorder: Clinical Decision Support in an African American Cohort.Semantic proximity Read ↗

ABCB1, CYP2B6, and CYP3A4 genetic polymorphisms do not affect methadone maintenance treatment in HCV-positive patients.Semantic proximity Read ↗

Genetic polymorphisms in the opioid receptor delta 1 (OPRD1) gene are associated with methadone dose in methadone maintenance treatment for heroin dependence.Semantic proximity Read ↗

Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.