Article
Impact of the Omics-Based Biomarkers on the Mirtazapine's Steady-State Concentration, Efficacy and Safety in Patients with Affective Disorders Comorbid with Alcohol Use Disorder.
Psychopharmacology bulletin - 16 Mar 2021
Zastrozhin M S, Skryabin VYu, Smirnov VYu, Zastrozhina A K, Kaverina E V, Klepikov D A, Grishina E A, Ryzhikova K A, Bure I V, Bryun E A, Sychev D A
Abstract excerpt
Introduction: Mirtazapine is commonly administered to patients with recurrent depressive disorder. Some of these patients do not show adequate response to the therapy with mirtazapine, whereas many of them experience dose-dependent adverse drug reactions. Previous research revealed that CYP2D6 is involved in the metabolism of mirtazapine, the activity of which is highly dependent on the polymorphism of the gene...
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