Article
Genotyping and phenotyping of CYP2D6 and CYP3A isoenzymes in patients with alcohol use disorder: correlation with haloperidol plasma concentration.
Drug metabolism and personalized therapy - 26 Sept 2017
Sychev Dmitry A, Zastrozhin Mikhail S, Miroshnichenko Igor I, Baymeeva Natalia V, Smirnov Valery V, Grishina Elena A, Ryzhikova Kristina A, Mirzaev Karin B, Markov Dmitry D, Skryabin Valentin Y, Snalina Nataliya E, Nosikova Polina G, Savchenko Ludmila M, Bryun Evgeny A
Abstract excerpt
BACKGROUND: Haloperidol is used for the treatment of alcohol use disorders in patients with signs of alcohol-related psychosis. Haloperidol therapy poses a high risk of adverse drug reactions (ADR). Contradictory data, which include the effects of genetic polymorphisms in genes encoding the elements of haloperidol biotransformation system on haloperidol metabolism rate and plasma drug concentration ratio, are...
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