Article
Relationship of the 1846G > A Polymorphism of the CYP2D6 Gene to the Equilibrium Concentration Levels of Haloperidol in Patients with Acute Alcoholic Hallucinosis.
Psychopharmacology bulletin - 4 Dec 2023
Parkhomenko A A, Zastrozhin M S, Skryabin VYu, Petukhov A E, Pozdniakov S A, Ivanchenko V A, Zaytsev I A, Bure I V, Bochkov P O, Akmalova K A, Smirnov V V, Bryun E A, Sychev D A
Abstract excerpt
Haloperidol is currently used in addictology for the treatment of acute psychotic disorders, including acute alcoholic hallucinosis. The use of haloperidol is often accompanied by the occurrence of adverse drug reactions (ADRs). There is evidence that CYP2D6 isoenzyme is involved in the biotransformation of haloperidol. Aim: The study aimed to evaluate the relationship of 1846G > A polymorphism of the CYP2D6 gene...
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