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Innovative mouse models for the tumor suppressor activity of Protocadherin-10 isoforms

25 Apr 2022

Abstract excerpt

BACKGROUND: Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative splice isoforms differ in the size of these cytoplasmic domains. In view of the compelling evidence for gene silencing of protocadherins in human tumors, we started investigations on Pcdh...

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PMID: 35468745
DOI: 10.1186/s12885-022-09381-y

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