Article
Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2021
Hanemaaijer Evelyn S, Margaritis Thanasis, Sanders Karin, Bos Frank L, Candelli Tito, Al-Saati Hanin, van Noesel Max M, Meyer-Wentrup Friederike A G, van de Wetering Marc, Holstege Frank C P, Clevers Hans
Abstract excerpt
Neuroblastoma is the most common extracranial solid tumor and accounts for ∼10% of pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is generally accepted that neuroblastoma derives from the neural crest and should thus be considered an embryonal malignancy. About 50% of primary neuroblastoma tumors arise in the adrenal gland. Here, we present an atlas of the developing...
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