Article
The role and expression of the protocadherin-alpha clusters in the CNS.
Current opinion in neurobiology - 1 Jun 2006
Hirayama Teruyoshi, Yagi Takeshi
Abstract excerpt
The clustered protocadherins comprise the largest subfamily of the cadherin superfamily and are predominantly expressed in the nervous system. The family of clustered protocadherins (clustered Pcdh family) is substructured into three distinct gene arrays in mammals: Pcdh-alpha, Pcdh-beta, and Pcdh-gamma. These are regulated by multiple promoters and cis-alternative splicing without DNA recombination. Pcdh-alpha...
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