Article
Mutant NPM1 Maintains the Leukemic State through HOX Expression.
Cancer cell - 10 Sept 2018
Brunetti Lorenzo, Gundry Michael C, Sorcini Daniele, Guzman Anna G, Huang Yung-Hsin, Ramabadran Raghav, Gionfriddo Ilaria, Mezzasoma Federica, Milano Francesca, Nabet Behnam, Buckley Dennis L, Kornblau Steven M, Lin Charles Y, Sportoletti Paolo, Martelli Maria Paola, Falini Brunangelo, Goodell Margaret A
Abstract excerpt
NPM1 is the most frequently mutated gene in cytogenetically normal acute myeloid leukemia (AML). In AML cells, NPM1 mutations result in abnormal cytoplasmic localization of the mutant protein (NPM1c); however, it is unknown whether NPM1c is required to maintain the leukemic state. Here, we show that loss of NPM1c from the cytoplasm, either through nuclear relocalization or targeted degradation, results in...
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