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Article

Functional Analysis of Spike from SARS-CoV-2 Variants Reveals the Role of Distinct Mutations in Neutralization Potential and Viral Infectivity.

Viruses - 13 Apr 2022

Kuzmina Alona, Wattad Seraj, Engel Stanislav, Rosenberg Elli, Taube Ran

Abstract excerpt

Enhanced viral transmission and escape from vaccine-elicited neutralizing antibodies drive worldwide spread of SARS-CoV-2 variants and promote disease progression. However, the impact of specific spike mutations that are carried by different viral variants on viral infectivity and neutralization sensitivity has not been completely defined. Here, we use pseudoviruses to assess the contribution of spike mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35458533
DOI: 10.3390/v14040803
PMCID: PMC9030214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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