Article
SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape.
Cell - 29 Apr 2021
Li Qianqian, Nie Jianhui, Wu Jiajing, Zhang Li, Ding Ruxia, Wang Haixin, Zhang Yue, Li Tao, Liu Shuo, Zhang Mengyi, Zhao Chenyan, Liu Huan, Nie Lingling, Qin Haiyang, Wang Meng, Lu Qiong, Li Xiaoyu, Liu Junkai, Liang Haoyu, Shi Yi, Shen Yuelei, Xie Liangzhi, Zhang Linqi, Qu Xiaowang, Xu Wenbo, Huang Weijin, Wang Youchun
Abstract excerpt
The 501Y.V2 variants of SARS-CoV-2 containing multiple mutations in spike are now dominant in South Africa and are rapidly spreading to other countries. Here, experiments with 18 pseudotyped viruses showed that the 501Y.V2 variants do not confer increased infectivity in multiple cell types except for murine ACE2-overexpressing cells, where a substantial increase in infectivity was observed. Notably, the...
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