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Article

SARS-CoV-2 spike E156G/Δ157-158 mutations contribute to increased infectivity and immune escape.

Life science alliance - 1 Jul 2022

Mishra Tarun, Dalavi Rishikesh, Joshi Garima, Kumar Atul, Pandey Pankaj, Shukla Sanjeev, Mishra Ram K, Chande Ajit

Abstract excerpt

Breakthrough infections by emerging SARS-CoV-2 variants raise significant concerns. Here, we sequence-characterized the spike gene from breakthrough infections that corresponded to B.1.617 sublineage. Delineating the functional impact of spike mutations revealed that N-terminal domain (NTD)-specific E156G/Δ157-158 contributed to increased infectivity and reduced sensitivity to vaccine-induced antibodies. A...

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Source

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Identifiers

PMID: 35296517
DOI: 10.26508/lsa.202201415
PMCID: PMC8927725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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