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Article

LYN- and AIRE-mediated tolerance checkpoint defects synergize to trigger organ-specific autoimmunity

28 Aug 2016

Abstract excerpt

Studies of the genetic factors associated with human autoimmune disease suggest a multigenic origin of susceptibility; however, how these factors interact and through which tolerance pathways they operate generally remain to be defined. One key checkpoint occurs through the activity of the autoimmune regulator AIRE, which promotes central T cell tolerance. Recent reports have described a variety of...

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PMID: 27571405
DOI: 10.1172/jci84440

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