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Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

21 Apr 2022

Abstract excerpt

Chromatin accessibility plays an essential role in controlling cellular identity and the therapeutic response of human cancers. However, the chromatin accessibility landscape and gene regulatory network of pancreatic cancer are largely uncharacterized. Here, we integrate the chromatin accessibility profiles of 84 pancreatic cancer organoid lines with whole-genome sequencing data, transcriptomic sequencing data...

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PMID: 35449156
DOI: 10.1038/s41467-022-29857-6

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