Article

Organoid Pharmacotyping of Pancreatic Cancer Enables Functional Precision Oncology and Drug Repurposing

2025-12-03

Abstract excerpt

<h4>Purpose</h4> Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest malignancies, with limited benefit from current cytotoxic regimens and poor predictive value of genomics alone. Patient-derived organoids (PDOs) represent a promising platform for functional precision oncology, yet systematic pharmacotyping of genomically annotated PDAC PDOs remains sparse. <h4>Experimental Design</h4> We estab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd81829b-ac57-5f17-9b55-2b01ded5d8ab
DOI: 10.64898/2025.12.01.691211

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Organoid Pharmacotyping of Pancreatic Cancer Enables Functional Precision Oncology and Drug RepurposingDOI 10.64898/2025.12.01.691211Read

Deep molecular characterization linked to drug response profiling of pancreatic ductal adenocarcinoma using patient-derived organoidsSemantic proximity Read

Combining molecular characteristics and therapeutic analysis of PDOs predict clinical responses and guide PDAC personalized treatmentSemantic proximity Read

Integrated Patient-Derived Models Delineate Individualized Therapeutic Vulnerabilities of Pancreatic CancerSemantic proximity Read

A pancreatic cancer organoid biobank links multi-omics signatures to therapeutic response and clinical evaluation of statin combination therapySemantic proximity Read

Pancreatic adenocarcinoma human organoids share structural and genetic features with primary tumorsSemantic proximity Read

Organoids for Functional Precision Medicine in Advanced Pancreatic Cancer.Semantic proximity Read

The vulnerabilities of chemotherapy resistant pancreatic cancer revealed by organoids of pre- and post-neoadjuvant therapy.Semantic proximity Read

Pan-Cancer PDOs Preserve Tumor Heterogeneity and Uncover Therapeutic VulnerabilitiesSemantic proximity Read

Human Organoids Share Structural and Genetic Features with Primary Pancreatic Adenocarcinoma TumorsSemantic proximity Read

Patient-derived urachal cancer organoids for personalized drug screeningSemantic proximity Read

Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label therapySemantic proximity Read

Molecular and Phenotypic Profiling for Precision Medicine in Pancreatic Cancer: Current Advances and Future PerspectivesSemantic proximity Read