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Article

Pancreatic Cancer Heterogeneity Can Be Explained Beyond the Genome

5 Apr 2019

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) remains a major health problem because it induces almost systematic mortality. Carcinogenesis begins with genetic aberrations which trigger epigenetic modifications. While genetic mutations initiate tumorigenesis, they are unable to explain the vast heterogeneity observed among PDAC patients. Instead, epigenetic changes drive transcriptomic alterations that can regulate the...

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PMID: 31024848
DOI: 10.3389/fonc.2019.00246

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