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Article

atpE Mutation in Mycobacterium tuberculosis Not Always Predictive of Bedaquiline Treatment Failure.

Emerging infectious diseases - 1 May 2022

Le Ray Laure Fournier, Aubry Alexandra, Sougakoff Wladimir, Revest Matthieu, Robert Jérôme, Bonnet Isabelle, Veziris Nicolas, Morel Florence

Abstract excerpt

We report the emergence of an atpE mutation in a clinical Mycobacterium tuberculosis strain. Genotypic and phenotypic bedaquiline susceptibility testing displayed variable results over time and ultimately were not predictive of treatment outcome. This observation highlights the limits of current genotypic and phenotypic methods for detection of bedaquiline resistance.

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Identifiers

PMID: 35447056
DOI: 10.3201/eid2805.212517
PMCID: PMC9045433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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