Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2-mutation carriers.

doi:10.1002/cam4.5430

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Lack of impact of the ALDH2 rs671 variant on breast cancer development in Japanese BRCA1/2-mutation carriers.

Cancer medicine - 1 Mar 2023

Mori Tomoharu, Okamoto Yusuke, Mu Anfeng, Ide Yoshimi, Yoshimura Akiyo, Senda Noriko, Inagaki-Kawata Yukiko, Kawashima Masahiro, Kitao Hiroyuki, Tokunaga Eriko, Miyoshi Yasuo, Ohsumi Shozo, Tsugawa Koichiro, Ohta Tomohiko, Katagiri Toyomasa, Ohtsuru Shigeru, Koike Kaoru, Ogawa Seishi, Toi Masakazu, Iwata Hiroji, Nakamura Seigo, Matsuo Keitaro, Takata Minoru

Abstract excerpt

The aldehyde degrading function of the ALDH2 enzyme is impaired by Glu504Lys polymorphisms (rs671, termed A allele), which causes alcohol flushing in east Asians, and elevates the risk of esophageal cancer among habitual drinkers. Recent studies suggested that the ALDH2 variant may lead to higher levels of DNA damage caused by endogenously generated aldehydes. This can be a threat to genome stability and/or cell...

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PMID: 36345163
DOI: 10.1002/cam4.5430
PMCID: PMC10067083

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