Aldehydes Pose a Threat to BRCA2 Mutation Carriers.

Abstract excerpt

Humans with inherited heterozygous BRCA2 mutations have an increased risk of developing cancer; however, what triggers carcinogenesis in these individuals is unclear. Tan et al. find that environmental and metabolic aldehydes pose a threat to these individuals by promoting degradation of wild-type BRCA2 protein, thereby predisposing them to genomic instability and perhaps to cancer.

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aldehydes
• Share to BRCA2 Protein
• Share to Breast Neoplasms