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Article

A common missense variant in BRCA2 predisposes to early onset breast cancer.

Breast cancer research : BCR - 1 Jan 2005

Górski Bohdan, Narod Steven A, Lubinski Jan

Abstract excerpt

INTRODUCTION: Mutations in the BRCA2 gene are one of the two major causes of hereditary breast cancer. Protein-truncating mutations of BRCA2 are usually deleterious and increase the risk of breast cancer up to 80% over a lifetime. A few missense mutations in BRCA2 are believed to have a similarly high penetrance, apart from more common neutral polymorphisms. It is often difficult to classify a particular sequence...

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Source

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Identifiers

PMID: 16280055
DOI: 10.1186/bcr1338
PMCID: PMC1410744

Genes

BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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