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Article

Pharmacogenetics may explain part of the interindividual variability of dobutamine pharmacodynamics in neonates.

British journal of clinical pharmacology - 1 Sept 2022

Hallik Maarja, Soeorg Hiie, Kahre Tiina, Murumets Ülle, Ilmoja Mari-Liis, Kipper Karin, Metsvaht Tuuli

Abstract excerpt

AIMS: To determine whether the known single nucleotide polymorphisms in adrenoreceptor associated genes affect the haemodynamic response to dobutamine in critically ill neonates. METHODS: Alleles in the known genetic single nucleotide polymorphisms in β1- and β2-adrenoceptor (AR) genes and Gs protein α-subunit gene (GNAS) possibly affecting inotropic effect were identified in patients of neonatal dobutamine...

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Identifiers

PMID: 35437830
DOI: 10.1111/bcp.15357

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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