Article

Pharmacogenetics may explain part of the interindividual variability of dobutamine pharmacodynamics in neonates

2022-01-26

Abstract excerpt

<h4>Aim: </h4> To determine whether the known single nucleotide polymorphisms in adrenoreceptor associated genes affect the hemodynamic response to dobutamine in critically ill neonates. <h4>Methods:</h4> Alleles in the known genetic single nucleotide polymorphisms in β1 and β2 adrenoceptor (AR) genes and Gs protein α-subunit gene (GNAS) possibly affecting inotropic effect were identified in patients of neonatal d...

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Literature Corpus work: 504b2319-9a5c-592e-9d50-8a6473dc1893
DOI: 10.22541/au.164317251.14245872/v1

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