Article
Comparative analysis of the biological characteristics of three CV-A10 clones adaptively cultured on Vero cells.
Journal of medical virology - 1 Aug 2022
Zhao Hong, Yang Ting, Yue Lei, Li Hua, Xie Tianhong, Xiang Hong, Wang Jie, Wei Xingchen, Zhang Yuhao, Xie Zhongping
Abstract excerpt
Coxsackievirus A10 (CV-A10) is a major pathogen that causes hand, foot, and mouth disease. There are no effective therapeutic drugs for CV-A10 infection; therefore, CV-A10 vaccines should be developed. Previously, we isolated a CV-A10 strain (N25) that can be cultured on Vero cells. In this study, the N25 strain was plaque-purified three times from Vero cells, and three clones were selected for adaptive culture....
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