Characterization of live-attenuated Japanese encephalitis vaccine virus SA14-14-2.

doi:10.1016/j.vaccine.2014.03.074

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Article

Characterization of live-attenuated Japanese encephalitis vaccine virus SA14-14-2.

Vaccine - 13 May 2014

Yang Dong, Li Xiao-Feng, Ye Qing, Wang Hong-Jiang, Deng Yong-Qiang, Zhu Shun-Ya, Zhang Yu, Li Shi-Hua, Qin Cheng-Feng

Abstract excerpt

The live attenuated Japanese encephalitis (JE) vaccine SA14-14-2 was licensed decades ago and now approved for clinical use in most JE endemic countries. Large-scale clinical trials demonstrate ideal safety and efficacy profile of this Chinese vaccine. The SA14-14-2 vaccine was derived from a virulent strain SA14 after hundreds of serial passaging in cells and animals, concern about virulence reversion remains...

Topics

Animals
Brain
Chlorocebus aethiops
Encephalitis Virus, Japanese
Genome, Viral
Japanese Encephalitis Vaccines
Mice
Mice, Inbred BALB C
Mutation
Serial Passage
Vaccines, Attenuated
Vero Cells
Viral Plaque Assay
Virulence

Source

Open in PubMed

Identifiers

PMID: 24709585
DOI: 10.1016/j.vaccine.2014.03.074

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