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Serial passaging in vitro generates a Vero cell-adapted coxsackievirus A6 strain with distinct phenotypic characteristics.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Xia Sijin, Shu Rongyu, Sun Yihao, Wu Jiahui, Wang Mengjun, Du Yaxin, Yang Dongsheng, Guo Jing, Zhang Bo, Shen Shuo

Abstract excerpt

Background: Coxsackievirus A6 (CVA6) has emerged as a major etiological agent of hand, foot, and mouth disease (HFMD), yet no commercial vaccine is available against CVA6. CVA6 exhibits poor adaptability to Vero cells, a WHO-approved substrate for human vaccine production, and the mechanisms underlying its infectivity and pathogenesis remain incompletely understood. Methods: A Vero cell-adapted CVA6 strain was...

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Identifiers

PMID: 42131302
DOI: 10.3389/fcimb.2026.1810260
PMCID: PMC13161056

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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