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Article

Identification of Critical Amino Acids of Coxsackievirus A10 Associated with Cell Tropism and Viral RNA Release during Uncoating.

Viruses - 18 Oct 2023

Pei Jie, Liu Rui-Lun, Yang Zhi-Hui, Du Ya-Xin, Qian Sha-Sha, Meng Sheng-Li, Guo Jing, Zhang Bo, Shen Shuo

Abstract excerpt

Coxsackievirus A10 (CV-A10) is a prevailing causative agent of hand-foot-mouth disease, necessitating the isolation and adaptation of appropriate strains in cells allowed for human vaccine development. In this study, amino acid sequences of CV-A10 strains with different cell tropism on RD and Vero cells were compared. Various amino acids on the structural and non-structural proteins related to cell tropism were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37896891
DOI: 10.3390/v15102114
PMCID: PMC10611408

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