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Article

Adaptation of a live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes.

Virus research - 15 Jan 2021

Anwar Muhammad Naveed, Guo Shuang, Xin Wang, Hameed Muddassar, Wahaab Abdul, Ma Xiaochun, Khan Aman Ullah, Rahman Sajid Ur, Shao Donghua, Li Zongjie, Liu Ke, Li Beibei, Qiu Yafeng, Ma Zhiyong, Wei Jianchao

Abstract excerpt

The SD12-F120 is a live-attenuated genotype I strain of Japanese encephalitis virus (JEV) and was obtained by serial passage of wild-type strain SD12 on BHK-21 cells combined with multiple plaque purification and virulence selection in mice. The large scale production and vast clinical trials always demand ideal safety and efficacy profile of live-attenuated vaccines. In the present study, SD12-F120VC has...

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Identifiers

PMID: 33285172
DOI: 10.1016/j.virusres.2020.198256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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