Article
The single-cell pathology landscape of breast cancer.
Nature - 1 Feb 2020
Jackson Hartland W, Fischer Jana R, Zanotelli Vito R T, Ali H Raza, Mechera Robert, Soysal Savas D, Moch Holger, Muenst Simone, Varga Zsuzsanna, Weber Walter P, Bodenmiller Bernd
Abstract excerpt
Single-cell analyses have revealed extensive heterogeneity between and within human tumours1-4, but complex single-cell phenotypes and their spatial context are not at present reflected in the histological stratification that is the foundation of many clinical decisions. Here we use imaging mass cytometry5 to simultaneously quantify 35 biomarkers, resulting in 720 high-dimensional pathology images of tumour...
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