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Article

HLA-B27 may modulate the interaction between ERAP1 polymorphisms and smoking in ankylosing spondylitis patients.

Molecular biology reports - 1 Jul 2022

Fernández-Torres Javier, Zamudio-Cuevas Yessica, Montaño-Armendariz Nathalie, Luján-Juárez Iván Alejandro, Sánchez-Sánchez Roberto, Martínez-Flores Karina

Abstract excerpt

BACKGROUND: Ankylosing spondylitis (AS) is an autoimmune disease that affects the enthesis and synovial membrane of the spine, the sacroiliac vertebrae and peripheral joints. Genetic susceptibility to AS is mainly due to the presence of the HLA-B*27 (B27) allele, and endoplasmic reticulum aminopeptidase-1 (ERAP-1) plays a key role in antigen processing and presentation to HLA class I molecules. Tobacco...

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Share to Aminopeptidases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to HLA-B27 Antigen

Share to Minor Histocompatibility Antigens

Share to Polymorphism, Single Nucleotide

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Share to Spondylitis, Ankylosing

Source

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Identifiers

PMID: 35430705
DOI: 10.1007/s11033-022-07456-4
PMCID: PMC9013272

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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