Article
A proposed HLA-B*27 screening method for ankylosing spondylitis detection based on tag-single nucleotide polymorphisms: a preliminary study.
Molecular biology reports - 1 Dec 2021
Martínez-Nava Gabriela Angélica, Zamudio-Cuevas Yessica, Terrazas-Ontiveros Ninoska Aleida, Martínez-Flores Karina, Espinosa-Morales Rolando, Mijares-Díaz Fernando, Juárez-Barreto Shaila Monserrat, Lozada-Pérez Carlos, Valdés-Flores Margarita, Sánchez-Sánchez Roberto, Hidalgo-Bravo Alberto, Fernández-Torres Javier
Abstract excerpt
BACKGROUND: Ankylosing spondylitis (AS) is a type of inflammatory arthritis that affects primarily the spine. There is a strong association of the HLA-B*27 allele with AS pathogenesis, but recent studies have demonstrated the participation of ERAP1 gene in the genetic susceptibility. The aim of this study was to determine whether HLA-B tag-single nucleotide polymorphisms (SNPs) and ERAP1-related genetic...
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