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Article

Mutation rate of SARS-CoV-2 and emergence of mutators during experimental evolution

1 Jan 2022

Abstract excerpt

Abstract Background and objectives To understand how organisms evolve, it is fundamental to study how mutations emerge and establish. Here, we estimated the rate of mutation accumulation of SARS-CoV-2 in vitro and investigated the repeatability of its evolution when facing a new cell type but no immune or drug pressures. Methodology We performed experimental evolution with two strains of SARS-CoV-2, one carrying...

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PMID: 35419205
DOI: 10.1093/emph/eoac010

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