Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mutational dynamics of the SARS-CoV-2 virus in serial passages in vitro.

Virologica Sinica - 1 Apr 2022

Sonnleitner Sissy Therese, Sonnleitner Stefanie, Hinterbichler Eva, Halbfurter Hannah, Kopecky Dominik B C, Koblmüller Stephan, Sturmbauer Christian, Posch Wilfried, Walder Gernot

Abstract excerpt

Since its outbreak in 2019, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) keeps surprising the medical community by evolving diverse immune escape mutations in a rapid and effective manner. To gain deeper insight into mutation frequency and dynamics, we isolated ten ancestral strains of SARS-CoV-2 and performed consecutive serial incubation in ten replications in a suitable and common cell line and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to COVID-19
Share to Genome, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phylogeny

Share to SARS-CoV-2

Share to Serial Passage

Share to Spike Glycoprotein, Coronavirus

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 35277373
DOI: 10.1016/j.virs.2022.01.029
PMCID: PMC8800542

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mutational dynamics of the SARS-CoV-2 virus in serial passages in vitro.PMID 35277373Read ↗

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolutionSemantic proximity Read ↗

Long-term serial passaging of SARS-CoV-2 reveals signatures of convergent evolution.Semantic proximity Read ↗

Convergent Evolution and Host-Limiting Impacts of SARS-CoV-2 Revealed by Cellular Experiments.Semantic proximity Read ↗

SARS-CoV-2 mutations acquired during serial passage in human cell lines are consistent with several of those found in recent natural SARS-CoV-2 variantsSemantic proximity Read ↗

Genetic drift in the genome of SARS COV-2 and its global health concern.Semantic proximity Read ↗

Collaboration Between Host and Viral Factors Shape SARS-CoV-2 EvolutionSemantic proximity Read ↗

Evolution of viral quasispecies during SARS-CoV-2 infection.Semantic proximity Read ↗

Mutational induction in SARS-CoV-2 major lineages by experimental exposure to neutralising sera.Semantic proximity Read ↗

Impact of prolonged infection on SARS-CoV-2 evolution.Semantic proximity Read ↗

Are the original SARS-CoV-2 novel mutants from in vitro culture able to escape the immune response?Semantic proximity Read ↗

SARS-CoV-2 evolution during prolonged infection in immunocompromised patientsSemantic proximity Read ↗

What Has SARS-CoV-2 Taught Us About Evolution?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.