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Article

Replication of the coronavirus genome: A paradox among positive-strand RNA viruses.

The Journal of biological chemistry - 1 May 2022

Grellet Emeline, L'Hôte India, Goulet Adeline, Imbert Isabelle

Abstract excerpt

Coronavirus (CoV) genomes consist of positive-sense single-stranded RNA and are among the largest viral RNAs known to date (∼30 kb). As a result, CoVs deploy sophisticated mechanisms to replicate these extraordinarily large genomes as well as to transcribe subgenomic messenger RNAs. Since 2003, with the emergence of three highly pathogenic CoVs (SARS-CoV, MERS-CoV, and SARS-CoV-2), significant progress has been...

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Identifiers

PMID: 35413290
DOI: 10.1016/j.jbc.2022.101923
PMCID: PMC8994683

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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