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Continuous and Discontinuous RNA Synthesis in Coronaviruses

6 Nov 2015

Abstract excerpt

Replication of the coronavirus genome requires continuous RNA synthesis, whereas transcription is a discontinuous process unique among RNA viruses. Transcription includes a template switch during the synthesis of subgenomic negative-strand RNAs to add a copy of the leader sequence. Coronavirus transcription is regulated by multiple factors, including the extent of base-pairing between transcription-regulating...

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PMID: 26958916
DOI: 10.1146/annurev-virology-100114-055218

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