Coronaviruses as DNA Wannabes: A New Model for the Regulation of RNA Virus Replication Fidelity

Abstract excerpt

Coronaviruses Contain the Largest Known RNA GenomesCoronaviruses (CoVs) are positive-sense single-stranded RNA viruses and contain the largest known RNA genomes, ranging from 27 to 32 kilobases in length.CoVs are capable of transspecies movement as evidenced by the Severe Acute Respiratory Syndrome coronavirus (SARS-CoV) epidemic in 2002-2003 [1,2].Additionally, the emergence of Middle East Respiratory Syndrome...

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