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Article

SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagy

29 Jun 2022

Abstract excerpt

A characteristic feature of COVID-19, the disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, is the dysregulated immune response with impaired type I and III interferon (IFN) expression and an overwhelming inflammatory cytokine storm. RIG-I-like receptors (RLRs) and cGAS-STING signaling pathways are responsible for sensing viral infection and inducing IFN production to...

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PMID: 35765167
DOI: 10.1002/jmv.27965

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