Article

Micronucleus Production, Activation of DNA Damage Response and cGAS-STING Signaling in Syncytia Induced by SARS-CoV-2 Infection

2021-10-12

Abstract excerpt

SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully understood. Here, we reported that viral infection could induce syncytia formation within cells expressing ACE2 and the SARS-CoV-2 spike protein, leading to the production of micronuclei with an average rate of ab...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 74883afc-04eb-509d-b307-d01ab9a4f93d
DOI: 10.21203/rs.3.rs-948332/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Micronucleus Production, Activation of DNA Damage Response and cGAS-STING Signaling in Syncytia Induced by SARS-CoV-2 InfectionDOI 10.21203/rs.3.rs-948332/v1Read

Micronucleus production, activation of DNA damage response and cGAS-STING signaling in syncytia induced by SARS-CoV-2 infectionSemantic proximity Read

SARS-CoV-2 spike protein–induced cell fusion activates the cGAS-STING pathway and the interferon responseSemantic proximity Read

SARS-CoV-2 and the DNA damage responseSemantic proximity Read

Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formationSemantic proximity Read

The multifaceted functions of cGASSemantic proximity Read

SARS-CoV-2 triggers DNA damage response in Vero E6 cellsSemantic proximity Read

Micronuclei induced by radiation, replication stress, or chromosome segregation errors do not activate cGAS-STINGSemantic proximity Read

From Cell to Symptoms: The Role of SARS-CoV-2 Cytopathic Effects in the Pathogenesis of COVID-19 and Long COVIDSemantic proximity Read

cGAS‐STING signaling in cell death: Mechanisms of action and implications in pathologiesSemantic proximity Read

SARS‐CoV‐2 ORF10 antagonizes STING‐dependent interferon activation and autophagySemantic proximity Read

Innate sensing of picornavirus infection involves cGAS-STING-mediated antiviral responses triggered by mitochondrial DNA releaseSemantic proximity Read

SARS-CoV-2 triggers DNA damage response in Vero E6 cellsSemantic proximity Read