Article
Predicting causal genes from psychiatric genome-wide association studies using high-level etiological knowledge.
Molecular psychiatry - 1 Jul 2022
Wainberg Michael, Merico Daniele, Keller Matthew C, Fauman Eric B, Tripathy Shreejoy J
Abstract excerpt
Genome-wide association studies have discovered hundreds of genomic loci associated with psychiatric traits, but the causal genes underlying these associations are often unclear, a research gap that has hindered clinical translation. Here, we present a Psychiatric Omnilocus Prioritization Score (PsyOPS) derived from just three binary features encapsulating high-level assumptions about psychiatric disease etiology...
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