Article
Early anterior cingulate involvement is seen in presymptomatic MAPT P301L mutation carriers.
Alzheimer's research & therapy - 10 Feb 2021
Clarke Mica T M, St-Onge Frédéric, Beauregard Jean-Mathieu, Bocchetta Martina, Todd Emily, Cash David M, Rohrer Jonathan D, Laforce Robert
Abstract excerpt
BACKGROUND: PET imaging of glucose metabolism has revealed presymptomatic abnormalities in genetic FTD but has not been explored in MAPT P301L mutation carriers. This study aimed to explore the patterns of presymptomatic hypometabolism and atrophy in MAPT P301L mutation carriers. METHODS: Eighteen asymptomatic members from five families with a P301L MAPT mutation were recruited to the study, six mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.