A new way of enhancing the thermostability of proteases.

doi:10.1038/324695a0

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Article

A new way of enhancing the thermostability of proteases.

Nature - 1 Jan 2000

Imanaka T, Shibazaki M, Takagi M

Abstract excerpt

Thermostability of enzyme can be enhanced by single amino acid substitutions. Recent advances in genetic engineering have made it possible to create novel proteins in a predictable manner where structural information for the protein is available. This 'protein engineering' has already been used t...

Topics

Amino Acid Sequence
Bacillus
Enzyme Stability
Genes
Genes, Bacterial
Kinetics
Models, Molecular
Mutation
Peptide Hydrolases
Protein Conformation
Species Specificity
Structure-Activity Relationship
Thermodynamics
Thermolysin

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