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Article

A new way of enhancing the thermostability of proteases.

Nature - 1 Jan 2000

Imanaka T, Shibazaki M, Takagi M

Abstract excerpt

Thermostability of enzyme can be enhanced by single amino acid substitutions. Recent advances in genetic engineering have made it possible to create novel proteins in a predictable manner where structural information for the protein is available. This 'protein engineering' has already been used to enhance enzyme thermostability, but it is usually not clear which amino acid substitutions should be made. We...

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PMID: 3540685
DOI: 10.1038/324695a0

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