Turning a mesophilic protein into a thermophilic one: a computational approach based on 3D structural features.

Abstract excerpt

In spite of considerable improvement of our understanding of factors responsible for protein thermostability, rational designing of thermostable variants of mesophilic proteins is not yet fully established. The present paper describes an effective computational strategy that we have developed to identify the most suitable mutations converting a chosen mesophilic protein into a thermophilic one starting from its...

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