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Article

Two exposed amino acid residues confer thermostability on a cold shock protein.

Nature structural biology - 1 May 2000

Perl D, Mueller U, Heinemann U, Schmid F X

Abstract excerpt

Thermophilic organisms produce proteins of exceptional stability. To understand protein thermostability at the molecular level we studied a pair of cold shock proteins, one of mesophilic and one of thermophilic origin, by systematic mutagenesis. Although the two proteins differ in sequence at 12 positions, two surface-exposed residues are responsible for the increase in stability of the thermophilic protein (by...

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PMID: 10802734
DOI: 10.1038/75151

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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