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Amplification of Extrachromosomal MYC Paralogs Shapes Immunosuppressive Tumor Microenvironment in Small Cell Lung Cancer

29 Apr 2025

Abstract excerpt

PURPOSE: Immunotherapy has demonstrated promise in small cell lung cancer (SCLC), but certain patients encounter limited benefits, highlighting the need for immunosuppressive biomarkers. Extrachromosomal circular DNA (ecDNA) promotes amplification of MYC paralogs (MYC, MYCN, and MYCL), driving cross-resistance in SCLC. In this study, we aim to investigate whether ecDNA-mediated MYC paralog amplification (ecMYC+)...

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PMID: 40299768
DOI: 10.1158/1078-0432.ccr-24-3399

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